DESCRIPTION OF TAXIFOLIN APPLICATION IN SPORTS

TAXIFOLIN – NEW POSSIBILITIES IN SPORTS FOOD

An important aspect of training sports working capacity and endurance, which determine the outcome in sports of high achievements, is to train a cardiovascular system in response to physical activities. Especially it is important during the competitive period maximum, so-called «loadings to the full».

Intensive physical activities demand for oxygen consumption of human body at the level exceeding 75 % the maximum values. A bottleneck in adaptation to physical activities is insufficient supply of working muscles by oxygen (a fabric hypoxemia), caused by insufficient inflow of blood to fabrics because of a microcirculation inefficiency.

At maximum loads there are metabolism infringements in fabrics. In muscles dairy acid reduces working capacity and complicates restoration after trainings.

According to performed researches, Taxifolin application allows to solve successfully such problems as:

• improves indicators of intrawarm haemodynamics, supply by myocardium blood
• promotes transition of pathological types of microcirculation in normal and, thus, optimizes fabric a blood-groove
• promotes blood-groove redistribution on small arteries, improving blood supply of ischemic sites in fabrics
• improves blood supply of muscles
• influences mechanics of breath and leads to improvement of ventilating function of lungs and gas structure of blood
• promotes increase РО2 (fractional pressure of oxygen), blood oxygenation

Researches of Taxifolin were conducted for the period of trainings and preparation for the international competitions of sportsmen from Russian Olympic teams in 2008 under the direction by members of medical board of the Russian Olympic committee of the doctor of medical sciences, the chair professor of physiotherapy exercises, sports medicine and physical training of the Russian state medical university of Parastaeva S.A.

The conclusion has been drawn that Taksifolin can be applied by professional sportsmen in doses up to 100-200 mg a day during the training cycle demanding development aerobic and anaerobic of endurance, and also during the competitive period when organism is at maximum loadings.

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Open Company "SPORTMED", the Center of sports medicine «Restart». 12/24/2007
Director V.V.Bazaev.  The doctor of sports medicine and S.M.Ledovsky's functional diagnostics.

..... The preparation of Taxifolin at course of application (on skiers of the top skills) within 4 months supported the general and sports working capacity, positively influenced factors limiting necessary physical activities. It is connected with the action of antioxidants which not only raise a tone, but also influence the restoration processes, especially, at possible display at sportsmen of a chronic overstrain of separate bodies and systems. On responses of sportsmen the preparation gives the raised tone, desire to train, self-trust and good state of health. The preparation allows to keep weight of a body at high physical activities without application of the steroid preparations forbidden МК the IOC. The preparation doesn't contain doping components and can be recommended for wide application in sports medicine, and also at employment by physical training for the purpose of borders expansion of adaptation to physical activities.

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Football club "Moscow" of 15.10.2007

Doctor FC "Moscow", the candidate of the medical sciences, the Deserved doctor of Russia A.A.ShChukin

In FC "Moscow" within 4 months (June – September, 2007) was applied a natural antioxidant dihydroquercetin. Application of the above-stated preparation in the course of trainings and competitions has shown its high effectiveness.

It is noted:
- Increase of the general and special working capacity (value judgment of sportsmen and an objective estimation on the basis of the given test loadings)

- Acceleration of processes of restoration after training and competitive loadings (the data interval kardio-metry);

- Positive reaction from outside immunal systems of sportsmen (decrease the level of colds on peak of the sports form);
- Improvement of microcirculation and expressed a capillary a protector action (the data of ultrasonic researches of the bottom extremities).

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RECOMMENDATIONS FROM SCIENTIFIC RESEARCH INSTITUTE OF SPORTS IN RUSSIA:
Application of a preparation "Taxifolin" duration of 2-3 weeks promotes increase in aerobic possibilities of sportsmen muscles of high qualification of cyclic sports, and also speed of restoration after intensive physical activities. On the basis of the received data it is recommended to use a preparation "Taxifolin", as an effective natural and safe antioxidant, capillary protectors and immunomodulators the sports connected with display both local, and global muscular endurance during the periods of intensive trainings, directed on increase in aerobic possibilities of muscles. During intensive physical activities the use of 400 mg/days of Taxifolin is recommended.

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«The Antidoping Center» the Ministries of sports, tourism and the youth policy of the Russian Federation of ph. +7 (499) 2677320 №-S042S operating till March, 23rd, 2012 has confirmed with an expert judgement that taxifolin isn't  the dope.

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The role of vitamins-antioxidants for sportsmen

Formation of free radicals in unlimited quantities can cause decrease in working capacity of the sportsmen specializing in sports with primary display of endurance. 
 Free radicals in the form of hydroperoxides of nonsaturated fat acids have toxic effect on biological membranes, breaking their functional lability. It leads to infringement of a power metabolism and permeability of membranes in working muscular cages and decrease working capacity that demands antioxidants correction by leading to increase of impellent activity of the person. 
 It is shown that antioxidant properties of biologically active preparations of antioxidants and bioflavonoids promote an increase of sports working capacity. Communication between level training a human body and its reaction to powerful physical activities is revealed. 
 Vitamins C and Е are the classical antioxidants blocking process of reoxidation of fat acids and possessing antiradical action. Taxifolin is a synergist of these vitamins, strengthening their influence in several times.

The basic way of development and perfection of impellent qualities still there is a physical training, but, it is obvious that the volume and intensity of training loadings cannot grow infinitely. From here there is a huge interest in any additional possibility to increase a special or general physical working capacity of sportsmen, opening thereby possibilities for intensification of training process. 

Cases when an ignorance and (or) owing a high motivation sportsmen resort to forbidden application in sports are frequent, subjecting the sports career, health and the future to be at high risk.

The duel of athletes on a ring causes rigid demands for a level of sportsmen's physical quality development. The basic physical qualities in contact kinds of single combats are force, speed and the endurance which high level creates preconditions for victory achievement in fight. 

     For modern kinds of single contact combats the change in intensity of loading and extremely high emotional background is typical, these circumstances are powerful inductors of peroxide processes, in general, and lipid peroxide oxidations, in particular.

Among other negative consequences there was noticed a decrease in efficiency of oxidizing phosphorylation, a substantial increase of concentration of dairy acid, a decrease of рН blood plasmas that, as it is known, limits duration of a physical activity.

Long physical activities cause also infringement of functions of the higher departments CNS. 

     Level of functionality of an organism cannot be raised only by increase in volume and intensity of physical activities even under condition of perfection of methods of training. Constant increase of volume of loadings can negatively be reflected in a functional condition and health of sportsmen, growth of sports results and to lead weariness.

Thus the great value in increase of physical working capacity, prevention of premature development of exhaustion and acceleration of processes of restoration after physical activities can be rationalisation of a food and use of antioxidants. 

     Increase of efficiency of functioning of antioxidants in an organism of sportsmen is capable to interfere with the negative effects caused by excessive activation of processes of oxidation of lipids in fabrics (POL) at intense muscular activity and by that to raise its stability to physical pressure. 

Considerable strengthening of formation of free radicals and activation POL is marked in a greater degree of the sportsmen which activity is connected with an endurance display during extensive work. In this connection the use of antioxidants as antistressful means is rather extended not only in clinical practice, but also allows to reduce effectively generation of free radicals and to prevent negative strengthening the POL and its plural effects at muscular activity. 

The Australian scientists have confirmed that vitamins - antioxidants can protect sportsmen during the strengthened trainings when they become more vulnerable for stresses and traumas, are tired more strongly, feel devastated, their attention suffers, and they need time for rest and forces restoration.

Reception of antioxidants protects a muscular fabric, including a myocardium, from oxidants stress caused by physical exercises. 

    Non-uniform supply of an organism by oxygen, hypoxemia, hyperoxia limiting character mental and physical activities are powerful inductors the POL. It is obvious that all these circumstances necessarily take place practically at any kind of sports activity. 

     Efficiency of preparation of sportsmen considerably raises at use antioxidant means. Its use allows to intensify training process, and also to increase volume and intensity of loading of precompetitive preparation at the expense of cumulative training effect directly on the eve of competitions.

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From the book «Experience of preparation for the championship of Russia on mountain run. A diary of the champion» Alexander Pavlovicha Bolhovitina – masters of sports of the international class. Penza, 2009

From medical products of treatment of a myshechno-painful syndrome appointment spasmolytic, vasodilating and improving processes of microcirculation preparations is shown: taxifolin plus vitamins

Schemes of pharmacological maintenance of sportsmen at various stages of preparation.
In the given section certain questions of the scientifically-proved application resolved (non-doping) pharmacological preparations for regulation of processes of restoration, preventive maintenance of repressure, reduction of terms of adaptation (as to physical activity, and changing conditions of environment), increases of mental stability and working capacity of sportsmen are taken in detail up.

The regenerative period:

The primary goals of pharmacological maintenance of sportsmen at a regenerative stage of a year cycle of uchebno-training process are:

Deducing of metabolic "slags" from an organism;
Treatment of repressure of various systems and bodies;

Preparation for perception of intensive physical and psychoemotional loadings.

From pharmacology to the decision of the specified problems are applied:
Vitamins A and Е - combined with a preparation "Digidrokvertsetin" - promote stimulation of oxidation-reduction processes and synthesis of some hormones. Vitamin C - apply to acceleration of adaptation to physical activities and for the purpose of avitaminosis preventive maintenance.

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THE ALL-RUSSIA SCIENTIFIC RESEARCH INSTITUTE OF PHYSICAL TRAINING AND SPORTS

The author: Portugalov Sergey Nikolaevich - the well-known Russian scientist, the author of some books, articles and other publications in the field of sports medicine and pharmacology, the candidate of medical sciences, the professor, the deputy director and a constant member of the Academic council of the All-Russia scientific research institute of physical training and sports (ВНИИФК) Moscow.

The poliadaptogennye BAA used in programs of a sports food.

Taxifolin is applied on 1-2 tab. after last loading and before a dream.
Taxifolin plus (vitamins Е and C) is applied in the preparatory, base, precompetitive and competitive period.

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The Moscow scientifically-practical centre of sports medicine
Laboratory of clinical pharmacology and doping control
THE BASIC PROPERTIES NEW NOT DOPE THE PREPARATIONS RECOMMENDED FOR APPLICATION IN SPORTS MEDICINE FOR INCREASE OF SPORTS WORKING CAPACITY AND ACCELERATION OF PROCESSES OF RESTORATION OF SPORTSMEN.
(CLINICAL RESEARCHES In 2000-2003)

THE MINISTRY OF THE HIGHER AND VOCATIONAL TRAINING The Penza state pedagogical University of V.G.Belinsky
Chair of theoretical bases of physical training of Bubnova T.V.
The basic questions of restoration of working capacity of sportsmen
Penza 2008

METHODICAL RECOMMENDATIONS.

For sports doctors, trainers, sportsmen, athletes, persons occupied with heavy physical work, military men, pilots of military and civil aircraft and other contingents, connected with climate change - the zone adaptation, working in conditions of a heat, a cold, a hypoxemia and other extreme conditions. Taxifolin  the powerful antioxidant serving for improvement of conductivity of capillaries.

At intensive physical activity is appointed on 2-3 tablets of preparation per day. The course of reception makes 3-4 weeks. The preparations containing vitamin complexes, at the use it is not necessary to chew. The dosage should be increased in 2-3 times in comparison with recommended for healthy people.

Taxifolin + vitamins C and Е. A powerful complex of antioxidants and bioflavonoids, strengthening and supplementing action each other. Dihydroquercitin - is a reference antioxidant. It possesses powerful anti-inflammatory and antiallergic properties, strengthens and restores a connecting fabric, promotes decrease in level of cholesterol, strengthens action of many useful substances (vitamin C and vitamin E); strengthens vessels and capillaries, improves microblood circulation, interferes with formation of blood clots, reduces the inflammatory phenomena in a prostate, strengthens immunity; protects from harmful influences a stomach and a liver, activates processes of regeneration mucous a stomach; renders the expressed preventive maintenance of the basic diseases of aging: a cancer, cardiovascular diseases, illnesses of a brain, etc.; raises stability of fabrics of an organism to damaging influence of the superfluous maintenance of sugar in blood, reduces probability of disease by a diabetes, and facilitates a current of already developed forms; has a positive influence on nervous system, makes active nervous processes.

Regular reception dihydroquercitin improves a functional condition of cardiovascular system, promotes decrease in arterial pressure, improvement and, as a result, an organism rejuvenation.
Reception is more preferable to sportsmen adaptogen in the form of tablets and capsules, than in spirit solutions.

Employees of laboratory of biologically active substances of R.D.Sejfulla, L.G.Bocharovoj, N.M.popovoj and I.I.Kondratevoj had been approved in sports practice preparations with the maintenance of dihydroquercitin which for a long time are used in the general and sports medicine for the purpose of acceleration of restoration and correction of working capacity of sportsmen. Preparations are registered as food additives and protected by the Patent (Sejfulla R. D. Ankudinova I.A., 1996) Reception of preparations promoted increase of level of special physical readiness and sports result, in particular at athletes and swimmers.              

The results received in this research have shown that all sportsmen marked increase in the general tone of an organism, adaptation to physical activities, desire to train. In competitions all sportsmen have improved the personal results.

In the course of studying these preparations it was revealed that their application is very useful for the persons who are engaged in mass improving physical training, and the persons suffering from neurocirculatory dystonia. It is established that persons who are regularly engaged in physical culture, course reception of a preparation with dihydroquercitin is accompanied by formation of optimization of system of blood circulation by a principle of increase of reserve possibilities of central haemodynamics at the most rational parity of warm emission and heart rate.

Maintenance of the raised blood supply of important bodies (a brain, a liver, extremities) in the course of performance of physical activities is carried out, apparently, at the expense of rational distribution of the increased warm emission. Such variant of functioning of the central and peripheral links of haemodynamics is provided, most likely, thanks to influence of a preparation on the central mechanisms of nejro-gumoralno-hormonal regulation, and also as a result of variety of the vascular reactions establishing necessary level of peripheral blood circulation through direct influence by "vitamin-P" on the general peripheral resistance. At experimental groups the positive training effect that allows to make the conclusion about expediency of its use for elimination of the phenomena of mental and physical overfatigue and optimisation of regenerative processes at the expense of normalisation of the device of blood circulation.

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METHODICAL RECOMMENDATIONS.
For sports doctors, trainers,
Sportsmen, to body builders and hard athletes.
THE MINISTRY OF THE HIGHER AND VOCATIONAL TRAINING
The Penza state pedagogical University of V.G.Belinsky
Chair of theoretical bases of physical training of Bubnova T.V.
The resolved medical products and BUD – for the aid to body builders and weightlifters.

Penza,   2009 г.

Among various pharmacological means which can be included in an arsenal of the body builders and weightlifters, there is one group of the preparations which in our opinion yet haven't got deserved popularity. These preparations of various structure unite one rather important for power sports, in particular for athletic gymnastics, property – they are capable to stimulate a capillary blood-groove, including in a muscular fabric. Growth of muscles in volume without fail should be accompanied by adequate blood supply. Development of a muscular capillary channel, blood-groove increase through capillaries is stimulated appreciably by physical activities of aerobic character and great volume (work on endurance). In body building it occurs at a stage of highvolume trainings to small scales, at trainings on development of a relief of muscles. At work on aerobic, power when there is a growth of muscular weight and increase in a diameter of muscles – capillary maintenance of their work essentially lags behind requirements of supply of a muscular fabric glucose and oxygen, and also deducing of disintegration products. The lack of a capillary network detains, thus, restoration at a stage of power work and interferes then high-grade aerobic work at a stage of development of a relief.

Without delivery in a muscle of nutrients and oxygen blood «building of a body» will not turn out. Therefore, since 2nd half of stage power (on development of volume of muscles) works and in first half volume (on a relief) works body builders can accept the preparations expanding a capillary network in muscles. This preparation is Dihydroquercitin Plus (vitamins) with the use of 2 tablets 3 times per day 20-30 minutes before meal within 30 days.